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We observed that these specific gene expression changes detected in WWOX knockdown cells can be reverted upon WWOX re-expression.

The protein quantification changes detected by SILAC were compared to the changes in PSR detected with RNA-seq upon SRSF1 overexpression.

Interestingly, when near-UV CD spectra were taken noticeable changes were detected upon tyrosine phosphorylation of the SH3 domain.

Highly selective fluorescent enhancement and distinct colorimetric change were detected upon the addition of bismuth ion (Bi3+) into the sensor solution in EtOH/CH3CN (1:4, v:v) at pH 5.0 7.0.

Thus, the relationship between peripheral BDNF levels and hippocampal neurogenesis appears to be far from linear, and changes in peripheral levels of BDNF may only be detected upon substantial changes in brain levels of this neurotrophin.

No noticeable changes in protein levels were detected upon α-amanitin treatment.

No change in JNK phosphorylation was detected upon ERK inhibition (Fig. S1).

ITC experiments were performed by stepwise titration of RGS14 RBD1.RBD2) (300 µM) into an adiabatic cell containing H-Ras (20 µM), and the heat energy change accompanying the reaction was detected upon each injection by comparison with a reference cell.

Distinct functional changes in these OYE variants were detected upon mutations at W116, known in native OYE1 to cause inversion of diastereoselectivity for (S -carvone reduction.

Similar improvements in enantioselectivity could also be detected upon amino acid changes at positions 191 (variant B6) and 130 (variant B7).

While a reduction of histone H3K27 trimethylation was found in plants lacking the NuRD component PICKLE (Zhang et al, 2008a) and knockdown of Mi2 in mammalian cells was shown to be associated with a decrease of H3K27 methylation at one target locus (Morey et al, 2008), no global changes in histone modifications have been detected upon loss of NuRD in mammalian cells (Kaji et al, 2006).

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