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Thus the cytoskeleton changes, cell migration and invasion, angiogenesis, proliferation and apoptosis, crosstalk pathways linking to Slit-Robo signaling need to be elucidated.
In addition to cell growth, morphological changes, cell migration, and continuous perfusion can lead to changes in matrix fiber arrangement and remodelling that also influence the physical properties of the internal scaffold [ 15].
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Using cell based assays they have been implicated in the establishment of cell polarity, cell-shape change, cell migration, phagocytosis, secretion, cell-cycle progression, cytokinesis and transcription [1].
15– 18 The cellular changes might be explained in part by changes in cell migration due to reduced neoangiogenesis and reduced expression of adhesion molecules and chemokines, as suggested previously.
The lack of major glycogene changes in cell migration between may indicate that the migrating cells were not actually differentiating, but rather just altering expression for the mechanics of migration.
Furthermore, since neutrophil migration was attenuated in the presence of dexamethasone, this observation provides further evidence that inflammatory vascular changes and cell migration do not contribute to the LPS-induced changes in miRNA expression.
To determine whether these changes trigger cell migration, quiescent NIH3T3 cells were wounded and allowed to migrate in the absence or presence of the compounds indicated in Fig. 1A (lower panels).
No evidence of major changes in cell migration was observed since most RNA levels for these marker genes did not change significantly (Fig 4A).
BACKGROUND: The mechanisms that govern directional changes in cell migration are poorly understood.
Overall, these results suggest that directional changes in cell migration rely on the precise gene regulation of adhesion.
Upon treatment with compound 12d, remarkable cell shape changes as cell migration and tube formation were elicited in HUVECs, consistent with vasculature damaging activity.
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