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If the clinical trial can study outcome changes due to a biological intervention, they can simultaneously be laboratories for examining the effects of system changes by including arms where such system modifications are made.
The phylogenetic analysis by maximum likelihood (PAML) with the codeml program was used to estimate synonymous and non-synonymous changes by including differences in codon usage and rate ratios of transition/transversion substitutions [ 29, 57].
Recommended for consideration: Some additional points were raised that may be considered at the authors' discretion: 7) Reviewer #2 suggests: "It would have been most interesting to chart the persistency of these proposed short term synaptic efficiency changes by including several post TMS fMRI session (considering they only lasted 5 minutes) and/or MEP assessments.
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Enteric CH4 emissions (g/d) and CH4 energy losses (as a proportion of GE intake) were not changed by including incremental levels of eugenol in the diet.
For the analysis of stillbirth, the estimate was not changed by including smoking and body mass index in the propensity score (table 3).
Additional logistic models were created to examine whether the magnitude of the odds ratios for diabetes status (for all subjects), diabetes duration (for all subjects) and insulin use (for the diabetic patients only) might change by including different sets of covariates.
Average annual nitrate-N levels were significantly lower among women who had lived in homes accidentally exposed to PCE from water distribution pipes (p <.0001), but odds ratios for nitrate-N exposure were not appreciably changed by including PCE exposure in the model (not shown).
Even though zero between-center variation in bias may have been observed in a simpler model, we proceeded with the more complex ones to check whether the variance estimates would change by including different terms into the model (e.g., inclusion of explanatory variables).
The results were not materially changed by including only the 23 415 episodes of cervical intraepithelial neoplasia in which the timing of the normal test results followed the recommendations (38 040 woman years at risk and 13 cases of cervical cancer; footnote to table 1).
Although the MCC changes induced by including new conformations to the ligand profiles seem to be negligible, the cumulative effect for VS experiments leads to a significant improvement of screening performance by up to 20% (Additional file 4: Figure S4).
Congress has an opportunity to change this by including in health care reform incentives for generic drug makers to compete in the biologics marketplace.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com