The idea of adding something new to your repertory of belongings - be it as tiny as a modish bottle opener or as large as a cashmere winter coat - seems to suggest by some process of osmosis a change bigger than itself: Life might open up with you in possession of this new item, or you yourself might be ever so slightly revised and adopt a whole new worldview.
Genes with fold change bigger than 2 were thought to be significantly disturbed genes responsive to oxygen supply.
Positive slopes and correlation coefficients are obtained in all comparisons; correlations are higher when fitting only to genes with real-time RT-PCR log2 fold-changes bigger than 0.5, becoming 0.6 when comparing only to Sato's study.
Significantly expressed RNAs have a fold change bigger than two with a FDR smaller than 0.1.
This way, for example if the threshold is set at 25%; number of regions with methylation change bigger than 25% and number of regions with methylation change less than 25% are compared considering the inverse correlation between expression and methylation at that certain gene.
DEGs between control and Smg6Δ/Δ ESC samples were determined using R-package DEGseq with the method MARS (MA-plot-based method with random sampling model), fold change cutoff = 2, P-value cutoff = 10−6, and absolute change bigger than 50 reads (Wang et al, 2010).
Comparing our current technological shift to historical technological shifts like the platform shift from mainframe to client server, the database shift from hierarchical to relational databases and then the infectious domino effect of applications, operating systems, infrastructure, networks and eventually PCs afterward, "The results of the change are bigger than the change", Horowitz said.
Yet measured by the past two decades' prosperity, it is clear that the more open and efficient markets created by that year's "Big Bang" have greatly helped the City in its quest to reign as a global financial hub.Now come predictions that changes even bigger than Big Bang are looming for Europe's financial markets.
Technology is bringing about wholesale changes "even bigger than the internet did 15 years ago," adds Ms Chapman-Pincher.
It was a pivotal generation too, the first to really focus on 3D graphics, representing a change arguably bigger than any since.
We have forgotten that we can change something bigger than our waistlines with the food choices we make: treat the environment well and eat with care, and the body will follow.
