As shown in Table 3, comparison of the resultant sequences with the revised Cambridge consensus sequence identified the known hypertension-associated 4435A>G mutation in the tRNAMet gene and other 41 known nucleoside changes, belonging to the Eastern Asian haplogroup G2a1.
Also tubular changes belong to the histological features of human diabetic nephropathy [ 12] and have been shown to predict disease progression in patients with type 2 diabetes and overt proteinuria [ 39].
What if the hearts and minds to be changed belonged to the 2.5 million elementary and secondary teachers of Brazil?
The genes affected by these changes belonged to a number of canonical pathways, the most prominent ones are implicated in schizophrenia and related disorders.
More specifically, the gene expression changes belonged to potentially inhibited functions centered on apoptosis of B-cells, cell death of leukocytes and atrophy of lymph glands.
For each pathway, we count the number of nucleotide changes belonging to each of the four categories (NN, NS, SN, and SS).
For example two cDNAs that displayed the highest fold changes belong to large clusters in the hemocyte library (Sf1H00035-3-1 and Sf1H02709-3-1, with 19 and 38 clones, respectively, decreased 3.2 and 2.2 fold, respectively).
The severest changes belong to case 6 (heavy oil and high permeability), whereas the least important changes are those of case 3 (light oil and low permeability).
Irrespective of which category the structural changes belong to, a quantitative method that could identify and characterize the energetics of structural changes at the precision level of well-defined local degrees of freedom is highly desirable.
Most of the credit for pushing these changes belongs to Defense Minister Karl-Theodor zu Guttenberg.
