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To elucidate how cardiomyocyte shape changes are regulated during this process, we engineered transgenes to label their apical and basolateral membranes.
Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process.
How these dynamic changes are regulated and the mechanisms by which the are effected are still outstanding questions.
These specific changes indicate that age-associated methylation changes are not simply based on random deterioration during ontogenic development although it is yet unknown how site-specific methylation changes are regulated.
How these morphological changes are regulated remains to be elucidated.
These changes are regulated by a complex network involving more than 120 genes [ 5, 7].
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Multiple examples can be found in natural systems e.g. in the lambda-phage where the change from lysogenic to lytic behaviour in response to environmental changes is regulated by a switching two-component circuit.
They also showed these changes were regulated via the macrophage mannose receptor [28], now known as the site for specific binding of N-linked C. albicans cell wall mannans [27].
The changes were regulated via distinct signaling transduction pathways [ 44].
We asked how the shear rate R due to topological changes is regulated in the wing blade.
Given the increase in intraprostatic adipocytes after TZD treatment, it was unclear whether these changes were regulated in adipocytes or prostate.
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