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Changes are inherent and inevitable in any living culture.
These genes retained an unmethylated status in GBM and grade II PXA, indicating that these DNA hypermethylation changes are inherent to these tumor samples.
Although it is likely that selective changes in a transcription factor must precede the subsequent evolution of the binding sites, we do not intend to argue that such adaptive changes are inherent to the protein outside of external factors.
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But whereas Hegel saw change and development as the expression of the world spirit, or Idea, realizing itself in nature and in human society, for Marx and Engels change was inherent in the nature of the material world.
Nor are the states at the start and end of this process necessarily some form of stasis or equilibrium, both because internal dynamics (such as ageing or evolution) may mean that change is inherent, and because other externally driven perturbations may disrupt the system before it can become fully adjusted.
The extended phenotype perspective together with the concepts of essential and exacerbating causes provides a frame of reference that can help distinguish the most important processes in oncogenesis from the variety and complexity of microenvironmental changes that are inherent to oncogenesis.
These include not only external environmental abuse (like chemicals and radiation) that lead to mutagenesis but also changes that are inherent to the double-stranded DNA form itself. Indeed, several forms of non-B DNA structural conformations resulting from repeat sequences have been demonstrated to be mutagenic and cause hereditary disorders (reviewed in [1], [2]).
While longitudinal curvature changes and twist are inherent to the geometry of the helices; the transverse curvature results from a consideration of boundary effects and the minimisation of the (expensive) membrane elastic energy.
These changes are clearly inherent because edge instability could not produce such effects.
The numerical results showed that there are inherent changes in the particle deposition profile in the spacer-filled channel due to variations in curvature.
Numerical results show that there are inherent changes in the hydrodynamic behavior of the spacer-filled channel due to curvature variations.
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