Your English writing platform
Discover LudwigSuggestions(1)
Exact(12)
We identified developmental-stage-specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice.
Our results suggest that a relatively small subset of age-regulated gene expression changes are conserved from mouse to man.
A small subset of gene expression changes are conserved in all three species, including robust age-dependent upregulation of the neuroprotective gene apolipoprotein D (APOD) and downregulation of the synaptic cAMP signaling gene calcium/calmodulin-dependent protein kinase IV (CAMK4).
Although a small subset of age-related gene expression changes are conserved from mouse to man, major changes in the expression of genes involved in neurotransmission have evolved in the primate cortex that are potentially relevant to age-related changes in cognition and vulnerability to neurodegeneration.
Therefore, it is of general interest whether such activity changes are conserved throughout evolution.
We show that these changes are conserved across species and provide biological evidence for reduced proteasome efficiency and a novel lengthening of S phase.
Similar(48)
We identified those genes whose expression changes were conserved between the untreated and PDGF-BB treated cells.
Non-supervised independent component analysis (ICA) of the whole dataset separated controls from NaCl-treated plants, regardless of the genotype, indicating that at least part of the transcriptional changes were conserved amongst all species (Figure 4A, IC4 represents the shared stress-related variability, while IC1 to IC3 captured genotype-related variability).
Even though several strain-specific metabolic changes were conserved in HFD-fed mice (e.g. lipids, choline, PC in C57BL/6 and oxoglutarate in DBA/2), adaptations to HFD also involved altered levels of different sets of metabolites specific to C57BL/6 (lactate), 129S6 (PUFAs, PC), BALB/c (β-hydroxybutyrate), DBA/2 (alanine, pyruvate), and C3H (phenylacetate, creatine).
These changes were conserved in three clones sequenced, suggesting that the observed differences are the result of strain variation.
Humans and dogs share an ancestrally related pathogenic basis for cancer, with pathognomonic genetic changes being conserved in both species [ 24].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com