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Taken together with the earlier finding that the undifferentiated ME-iPSCs and TF-iPSCs showed similar gene expression, our data suggest that these changes are acquired during differentiation.
These cells have to be expanded in vitro before transplantation and several studies demonstrated that long-term culture evokes continuous changes in MSC: proliferation rate decays, the cell size increases, differentiation potential is affected, chromosomal instabilities may arise and molecular changes are acquired.
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These studies indicated that more changes were acquired during the human infection process.
The genomes of the cladosporin-sensitive parental clone and cladosporin-resistant clones were compared using a microarray that has the capacity to reveal most genomic changes that are acquired by the resistant strains, including copy number variants, deletions, small insertion/deletion events, and single-nucleotide polymorphisms (Dharia et al., 2009).
Along the path of change helpers are acquired.
The spatial temperature distributions in the crystal and the temperature changes over time are acquired.
Rick Kline, a partner at Goodwin Procter, which was supposed to be an underwriting counsel on the canceled IPO, believes we may see other situations where companies change course and are acquired while planning to go public.
As technology advances, the way in which leads are acquired also changes.
As such, the majority of methylation changes detected in cancer cells are acquired during neoplastic development and, therefore, specific to cancer.
Hallmarks of cancer are acquired via mutational changes that provide a potential tumor cell with a fitness advantage relative to normal cells within the same niche, thereby promoting the expansion of the tumor cell clone.
The host culture must also change as new skills and knowledge are acquired, if the full benefits of these are to be realised.
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CEO of Professional Science Editing for Scientists @ prosciediting.com