Large shifts of the peaks of many zinc finger residues were observed in the presence of polyA, whereas polyG generated small changes and polyC or polyU generated negligible changes (Fig 2D and Supplementary Fig S4).
However, when we looked between cohorts we found that approximately 40% of the probesets were significantly regulated in both cohorts (1,493 probesets (expect 78 by chance)) with a remarkable 98% concordance in the directionality of the gene changes (Figure 1 and supplementary tables S1 and S2).
Twenty-nine ofthef the 30 unique SNVs were found in CDSs (a total of 108 occurrences), and all but four resulted in nonsynonymous changes (table 1 and supplementary table S4, Supplementary Material online).
Within the EPIC control population, IGF2 Dmethylationtion levels decreased with age suggesting that loss of methylation is an acquired epigenetic change (Table 2 and Supplementary Material, Fig. S2).
GCP16, GCP170 (Ohta et al, 2003), DHHC14 (Fukata et al, 2004), DHHC18 (Fukata et al, 2004) and N-Ras, genes known to be related to DHHC9, showed a moderate decrease or no change (Table 1 and Supplementary Figure 1).
They exhibit bright green or yellow fluorescence as well as in thin films and in aggregates, suggesting the ISC is blocked due to morphology change (Supplementary Fig. 2 and Supplementary Table 1-2).
The expression levels of AIRE-independent control genes (PSMD4 and BAT2) were not changed (Fig. 2 and Supplementary Material, Fig. S6).
At Zt +6, 6467 genes were altered in the Snord116del cortex (Fig. 5A), but at Zt +16 only 3140 transcripts changed (Fig. 5B and Supplementary Material, Table S6).
These functions of Hmo1 are both coincident with early DNA replication and are mediated by its C-terminal domain (Figs 2 and 5), which is crucial for Hmo1-mediated DNA bending and architectural/topological changes (Supplementary Fig S5C and Fig S5D).
We provide a metadata checklist for database submission and publication of UViGs designed to be flexible enough to accommodate technological and methodological changes over time (Table 1 and Supplementary Table 1).
Our results indicate that the mode of climate groundwater interaction is very insensitive to relative changes in recharge (Fig. 2b and Supplementary Fig. 5), with only 5% of the Earth's land surface switching mode for a 50% relative change in recharge rate.
