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A number of approaches still remain unexplored in ET genetics, including the contribution of copy number variants, uncommon moderate-effect alleles, rare variant large-effect alleles (including Mendelian and complex/polygenic modes of inheritance), de novo and gonadal mosaicism, epigenetic changes, and noncoding variation.
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"From the RNAs we identified approximately one thousand new genes, both protein-coding and noncoding.
Many motif-finding methods would benefit from the alignment referencing provided by the HMM's scaffolding of annotation across coding and noncoding regions.
The thirty loci used in this study differ in the proportion of synonymous, replacement and noncoding sites.
Listed for each series (PT series SNP summary ) are the number of filtered ('Materials and methods') coding and noncoding SNPs.
These databases contain the chromosome sizes, genomic DNA and a set of reference gene models and noncoding RNAs.
Coding and noncoding RNAs indicated similar ratios of downregulated species, while they showed diversity of upregulated species).
Our studies have revealed that PSR expresses both potentially coding and noncoding transcripts, despite its largely heterochromatic composition.
Whereas for maternally expressed genes strong divergence of protein-encoding sequences is most prominent, paternally expressed genes exhibit substantial conservation of coding and noncoding sequences.
The findings in this study also suggest that the genomic distribution of SSR-associated indels is nonrandom across coding and noncoding regions.
RNA-seq is free from the probe-specific hybridization of microarrays, and has a broader dynamic range, allowing the unbiased detection of novel transcripts, both coding and noncoding.
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