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He refined his songs by playing the melody repeatedly, making changes and altering notes until it reached his satisfaction.
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A similar phenomenon has been shown for cancer, in which epigenetic alterations may precede genetic changes and alter genomic stability (Feinberg 2004).
And in 1993, when Microsoft decided to build its own on-line service, the Microsoft Network, it was beset by false starts, name changes, and altered plans.
For the full value of those works to be realised, the researchers found that residents would have to "buy into" the changes and alter their behaviour around energy use and sustainability – a great opportunity to engage with and educate residents.
(When questioned, a Mini representative noted that future editions of the car's GPS system will be aware of elevation and directional changes, and alter gear suggestions accordingly).
Many studies identified characteristic inflammatory changes and altered growth factor signaling in BPD such as initial influx of neutrophils into the lung followed by increased numbers of macrophages [27].
There is virtually no recognition among the foreign policy establishment here -- both inside and outside of government -- that something important has changed, and that the U.S. government must accept these changes and alter its policy accordingly.
In addition, epigenetic changes and altered circadian gene expression has been shown in the HFD fetal liver [51], [52].
Also changes in water content may be implicated (see " Water content, volume changes and altered vasculature").
Epigenetic changes and altered mRNA expression have previously been linked to FTD/ALS pathogenesis.
Recent rodent studies indicated that changes in the microbiota composition led to behavioral changes and altered levels of brain-derived neurotropic factor (BDNF) in different brain regions.
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