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However, when the patient showed disease progression with visceral metastases, IL-2 therapy was changed to systemic immunochemotherapy, but no biopsies of the treated lesions were obtained prior to initiation of systemic therapy to confirm a possible CR.
In two patients, CR of all except one lesion was achieved, one lesion in each of these patients was classified as not assessable: (1) in patient no. 1 (Table 4) disease progression occurred with visceral metastases, and IL-2 therapy was changed to systemic immunochemotherapy with temozolomide and IFN-a before the response of this single lesions could be assessed.
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The actions varied in scope from groundwork, through instigating change to systemic change.
However, as the relationship between systemic hemodynamics and microcirculation are not straightforward [25, 26], the assessment of microcirculation might also improve our understanding of the effects of passive mobilization beyond changes to systemic hemodynamics.
Regimen was changed to topical itraconazole and systemic intravenous itraconazole.
The service secretary will then be required to initiate any appropriate disciplinary action, a crucial change to deter systemic violations of the law.
In 19% treatment was changed, usually from surgery to systemic treatment.
"On the one hand the premier is saying that there's going to be systemic change to the system, and on the other, the government has just passed the three-strike laws that are going to increase incarceration," he said.
This shift is of course reflected in the change of name to Systemic Functional Linguistics.
There are lots of places to chip away at Dodd-Frank, until the changes add up to systemic risk.
Tillerson may have more empathy for Russia's position but that will be unlikely to change the systemic differences between the two countries".
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CEO of Professional Science Editing for Scientists @ prosciediting.com