Furthermore, alteration of these residues attenuated zinc binding and significantly changed the overall conformation of full-length RECQ1 protein.
The researchers had no way to know how those students, if they'd come, would have changed the overall findings.
Khan claims last year's election was rigged against him, although independent election observers do not think irregularities would have changed the overall result.
Yet even though the pay gap among college graduates hasn't changed, the overall pay gap between men and women has continued to close in the last 15 years.
Mr. Yoshimoto of the Japan Research Institute also said the sharp market moves Thursday had not changed the overall longer-term picture for recovery in Japan.
The meaning of a monument may change with context, he said, giving the example of the addition of a statue of three soldiers near the Vietnam Veterans Memorial in Washington that "many believed changed the overall effect of the memorial".
I changed the overall narrative for the opera, and always assumed I'd go back and rewrite the book to conform to the story in the opera, but I never got round to it.
Mr. Liebman said that officials did not do so this year because of the way they had changed the overall formula, but he said they would consider it in the future.
"We now know that there's a range of those places the aircraft isn't in, but that hasn't changed the overall probability that the aircraft is in the total search area," Dolan said.
Wang looks at the transformation of these teahouses from private businesses to collective ownership and how state policy and the proprietors' response to it changed the overall economic and social structure of the city.
The Soviet Union suspended negotiations with the United States to limit intercontinental nuclear weapons today, saying that deployment of Pershing II and cruise missiles in Europe has changed "the overall strategic situation," which must now be reexamined.
