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Of special interest in this regard would be, to unravel whether the SINE Ins227bp of the MSTN promoter would regulate MSTN expression via the generated CpG island and/or via changed target sites for transcriptional regulator(s).
The initial search was TBlastN [ 16] at JGI (http://genome.jgi-psf.org/pages/blast.jsf?db=Emihu1) with the following parameters changed: Target database: Emiliania huxleyi v1 scaffolds (unmasked), 'Filter low complexity regions' off, and 'Perform gapped alignment' on.
Thus, resistance at the cellular level might be, on the one hand, directly associated with the mode of action of the respective anticancer agent (such as changed target expression or target mutation).
Similar(57)
"Human bombs can change direction, can change targets.
"We could change targets at any point," Captain Mercer said.
He worries that the ring of steel will not deter attackers, but merely force them to change targets.
He suspects they merely prompt attackers to change targets, and reckons it makes more sense to invest in better intelligence.
Be ready to change targets.
"We changed our target," he said.
But Mr. Reid changed his target to the United States after the bombing of Afghanistan began.
But a bronze medal at the 2014 Commonwealth Games in Glasgow changed the target once again.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com