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The drug, TNX-901, changed sensitivity so that instead of reacting to half a peanut, patients had no reactions until they ate nine on average.
The altered sensitivity for ACh that was observed in Cx37−/− and Cx40−/− aortas may be due to i) a changed sensitivity of the aortic endothelial cells for ACh, ii) an altered eNOS expression level (in the Cx40−/− but not the Cx37−/− aortas) or iii) a changed sensitivity of the vascular smooth muscle cells for NO.
These results suggest that the changed sensitivity of lov1 mutants to cold temperature is, at least partially, conferred by the altered expression of COR15A and KIN1 genes and may be regulated by means of one of several CBF/DREB1-independent signalling pathways in the cold response [40].
It is known that the semi-dwarfism conferred by uzu is not due to changed sensitivity to GA but to brassinosteroids [ 19, 20].
In summary, the changed sensitivity for ACh, which was observed in Cx37−/− and Cx40−/− aortas, was not due to alterations at the smooth muscle level (e.g. a decreased sensitivity of the 'NO receptor' soluble guanylyl cyclase (sGC)) but likely reflected endothelial changes.
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The Bluetooth Tilt Wheel Laser mouse, however, adds a bit more oomph allowing you to change sensitivity between 400-, 800- 1200- and 1600dpi with no drivers!
In addition, this pattern suggests that the manipulation did not change sensitivity, but only shifted the decision criterion.
However, a difference in primer designs and PCR conditions may substantially change sensitivity and specificity of a particular marker for the detection of CIMP in CRC [25].
Fifthly, the responsibility to change (sensitivity) of the scale was not evaluated.
I changed my sensitivity levels to Teen.
Changed insulin sensitivity is a biological mechanism that may link membrane fluidity to diabetes risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com