The transcript levels of 4333 genes were significantly increased or reduced, of which the majority changed only during a specific developmental stage or in an individual tissue type.
Importantly, we observed that these spatially segregated clusters changed only during learning, while in pseudo-conditioned mice and in data collected prior to training, NC clusters remained relatively constant.
Button was alone for most of the race, and after making two perfect pit stops, the order at the top changed only briefly during the pit stops.
At a first glance, the data suggest that the sequence of conventional actins reached a nearly perfect evolutionary level in D. discoideum, which changed only marginally during further evolution to higher eukaryotes.
The length of the minor axis changed only negligibly during cold-rolling, see Fig. 4a.
The H3K4me1 and H3K4me2 marks are more widely distributed (80%and84%4%, respectively) than the H3K4me3 marks (62%), but the H3K4me2 and H3K4me1 levels changed only modestly during dehydration stress.
Despite an increasing median age of the patients and increased prevalence of comorbidity, overall 1- and 5-year survivals changed only little during the study time.
The characteristics of the seasonal variation in terms of the times for peak and trough changed only slightly during the study period, whereas the PTT ratio decreased substantially over time.
In such countries as South Africa, Brazil, Thailand, Uganda, and Vietnam, patients' health utility markedly increased right after the initiation of ART, and then changed only slightly during the first 6 months of treatment, before increasing rapidly again afterwards.
non-significant * p < 0.05 significant changes within ECAD ** p < 0.05 significant differences between both devices Levels of haemoglobin (MARS: p = 0.002; SPAD: p = 0.005), haematocrit (MARS: p = 0.005; SPAD: p = 0.016) and INR (MARS: p = 0.449; SPAD: p = 0.049) changed only slightly during ECAD, showing no significant differences between the devices.
As figure 4B shows, the percentage of patients receiving ULT within 6 and 12 months changed only marginally during the study period with APCs (95% CI) of −1.0% (−2.1% to 0.2%; p=0.100) and −0.8 (−1.6 to 0.1; p=0.07), suggesting that the management of incident gout patients has remained essentially the same over the past 16 years.
