The MI plate changes localisation in both SN (Additional file 8) and NSN (Additional file 9) oocytes (d' p') and Figure 4(b) (i' p')).
Expression of the BAG-1-binding fragment increased the nuclear localisation of endogenous BAG-1, whereas the non-binding fragment failed to change the localisation of the BAG-1 protein.
After cleavage, both N and C-terminal Beclin 1 fragments change their localisations and these fragments do not interact normally with Vps34, which is required for autophagy.
Subcellular localisation and degradation of SNAIL protein is regulated by phosphorylation (Zhou et al, 2004) but, likewise, 1,25(OH)2doesoes not change SNAIL protein localisation in SW480-ADH cells.
Single mutations for each individual residue in the αK helical region and double/quadruple mutations for hydrophobic residues did not change the Golgi/lysosomal localisation of EGFP-Irgm1 αK.
p62 has been reported to be phosphorylated at S266, T269 and S272, and these phosphorylations can change the cellular localisation of p62 [ 27].
Entire chromosomes, subchromosomal regions, and genes change their nuclear localisation during differentiation to acquire a cell-type-specific spatial organisation, contributing, as part of the epigenome, to the regulation of the cell functions [ 5– 8].
Using a Gdap1 − / − mouse, Niemann et al. demonstrate that a CNS-expressed Gdap1 paralogue changes its subcellular localisation under oxidative stress conditions to also act as a mitochondrial fission factor.
We found that EGFR is downregulated and subcellular localisation of EGFR changed from plasma membrane to cytoplasm in 81B-Fb cells.
Consistent with this, immunofluorescence microscopy revealed that subcellular localisation of EGFR changed from plasma membrane in UMSCC81B cells to almost cytoplasm in 81B-Fb cells in the presence of FBS.
Along with an increase in the overall expression level of EGFR, we observed a change in localisation from diffuse cytoplasmic to intense, punctate labelling in cytoplasmic and perinuclear areas (Figure 1B).
