Sentence examples for changed genes and from inspiring English sources
We observed that the number of significantly changed genes and the fold-induction of genes increased with increasing fatty acid chain length and degree of unsaturation.
To overcome these limitations we used an alternative approach where we compared the frequency of changed genes and their contribution to deviation from random distributions on the targeted chromosome with other chromosomes (see Materials and Methods).
Our study shows a clear hierarchy between unsaturated dietary fatty acids in terms of number of significantly changed genes and fold-induction of genes, with especially C22 6 behaving as a highly potent inducer of PPARα-dependent gene expression.
This scoring feature is useful to evaluate whether a Reporter Feature is enriched in significantly changed genes, and can also be used to detect features with outlier nodes.
A larger lmax will allow more interactions involving less significantly changed genes and result in more (but potentially less interesting) interactions, while a smaller lmax will have the reverse effect and only include interactions with highly significantly changed genes.
A cut off p value 0.05 was used to find statistically changed genes, and a 1.5 fold change showing at least one pair of doses at each time point was further applied to filter less significantly regulated genes.
DOI: http://dx.doi.org/10.7554/eLife.05899.001 Mutations change genes and provide the raw material for evolution.
The overlap between predicted target genes and significantly changed genes with fold change >1.5 and p<0.05 in hypothyroid mice is shown in Table 3.
In liver tissue we detected 483 significantly changed genes (283 were upregulated and 200 were downregulated).
They were selected to represent highly significantly changed genes, more moderately changed candidate genes, and based on the availability of commercial antibodies.
In contrast, sites that bind Insm1 only correlate poorly with changed gene expression and are frequently enriched in promoters.
