She changed industries from private equity investing to technology; she changed geographies by moving from New York to San Francisco; and she changed functions from M&A and investing to HR.
Here, we propose a novel method, called regulatory e vent-based G ene S et A nalysis (eGSA), to evaluate the significantly changed functions or pathways from diverse genomic data sets.
SNAP scores range from -100 (strongly predicted as neutral) to 100 (strongly predicted to change function); the distance from the binary decision boundary (0) measures the reliability of the effect.
For example, when the cytosolic protein IDE (insulin degrading enzyme) was engineered to relocalize to the mitochondria, it immediately changed its function from regulating plasma insulin levels to degrading peptides (Leissring et al. 2004).
This radiator, reversible thermal panel (RTP), which consists of flexible high thermal conductive graphite sheets and a single crystal shape memory alloy as a passive reversible actuator, changes its function from a radiator to a solar absorber by deploying/stowing the reversible fin upon changes in the heat dissipation and thermal environment.
The finding suggests that the visual cortex can dramatically change its function — from visual processing to language — and it also appears to overturn the idea that language processing can only occur in highly specialized brain regions that are genetically programmed for language tasks.
It is known that macrophages can change their function from the inflammatory M1 type that is the major source for pro-inflammatory cytokines to the healing M2 type during tissue injury or infection including DSS-induced colitis.
These regions have been extensively interrogated by mutagenesis to elucidate each SL's contributions to genomic RNA packaging, This has led to the concept that a structural switch occurs within the 5′-UTR; associated with the change in function from translation to encapsidation of the full-length RNA genome.
This negative argument against step by step evolution ignores longstanding evidence that evolution proceeds through changes of function from preceding systems.
Therefore, in this study, we are in agreement with Greeve and coworker that Seladin-1 was a caspase-3 substrate and following the induction of apoptosis by goniothalamin, Seladin-1 was believed to be cleaved and the expression increased; which may resulted in changes of function from anti-apoptotic to pro-apoptotic (as shown in this study).
