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Although systemic therapy has changed, efficacy of chemotherapy for metastatic disease has reached a plateau.
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Behaviour change is more likely if the individual believes in the importance or value of change (outcome expectations) and feels that they have the confidence or skills to change (efficacy expectations).
If patients had been prescribed other AEDs these were not changed till efficacy or tolerability was affected.
The addition of tumour necrosis factor-alpha (TNF) has dramatically changed the efficacy of the procedure in patients with extremity STS.
They are also provided with specific tools to facilitate change (efficacy expectations).
Weiner postulates that organisational readiness for change can be viewed as a psychological state that is shared by the members of the organisation, and in which they feel committed to implementing an organisational change (change commitment or 'willingness to change'), and are confident in their collective abilities to do so (change efficacy or 'ability to change').
We agree with the reviewer that we do not measure synaptic efficacy directly, but we have shown that using a protocol known to change synaptic efficacy does result in the predicted changes (Buch et al., 2011, J Neurosci).
Knowledge of the way our bodies process CBD also suggests that it interacts with enzymes in the liver in ways that may change the efficacy of a number of other drugs, from blood thinners to anticonvulsants, to antidepressants.
All of these methods were based on the hypothesis that certain patterns of activity may change synaptic efficacy.
We first examined whether aging could modify the transduction efficiency of our lentiviral vectors and/or change the efficacy of the promoter driving the expression of mutant Htt.
Moreover, infection with Sr in BALB/c mice did not change the efficacy of vaccination against Pb ANKA [ 153].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com