Exact(5)
Pulse EPR studies showed the membrane-bound dimer is the same as the crystal dimer, although the N-terminal helix changed conformation on membrane binding.
The most significant conformational changes were limited to the active site of the ribozyme, and the changed conformation requires only small additional movements to reach a proposed transition-state.
Having established that T40/IDE digestion produced CSR species, some of which possessed surfactant activity and changed conformation from α-helical to β-structures, we examined their ability as heterologous seeds to promote Aβ fibrilization.
Structurally and functionally, arsenite and ATO caused conformational changes and zinc loss on C3H1 and C4 zinc finger peptide and protein, respectively, whereas MMA III) changed conformation and displaced zinc on all three types of zinc fingers.
Notably, the two ribosome-associating cytoplasmic loops in Sec61α, between transmembrane helices 6 and 7 (loop 6/7) and transmembrane helices 8 and 9 (loop 8/9), have been built de novo, as they have changed conformation compared to isolated crystal structures of SecY (Van den Berg et al., 2004; Tsukazaki et al., 2008).
Similar(54)
For conformational changed structures, our method calculates a set of possibly changed conformations of interfaces.
Upon arrestin activation, several elements significantly change conformation, some becoming disordered in this state.
Figure 4 maps known functional elements and arrestin switches (ASw, regions that significantly change conformation upon activation) on arrestin-3 structure.
The biological function of proteins requires the ability to change conformation [17].
This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction.
Several regions of DR1 were predicted by this analysis to change conformation substantially upon loss of bound peptide.
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