Sentence examples for changed by histone from inspiring English sources

The discovery of LSD1 has revolutionized the concept of histone methylation as a dynamically regulated process under enzymatic control, rather than chromatin marks that could only be changed by histone replacement.

First, chromatin can be changed by post-translational modification of histones through the action of histone-modifying enzymes.

Since there is a wide variety of histones, chromatin structure might change by changing the combination of histones.

Histone acetylation is a major epigenomic change controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs).

Structural changes triggered by histone H3 acetylation lead to a loosening of the compact wrapping of DNA, thereby giving transcription factors and RNA polymerase access to the DNA-binding elements for transcription [27,28].

Current studies have shown that DNA methylation and histone modifications could change by the metabolic or nutritional disorders and other environmental factors, thereby affecting the development of the pancreatic β cell and the function of insulin secretion to cause the decline of the sensitivity of insulin response, and ultimately lead to the occurrence of T2D.

Furthermore, epigenetic changes caused by histone-modifying enzymes were shown to modulate angiogenesis as well.

Such event globally changes histone modifications, by supporting genomic instability in these patients [ 59– 61].

Since neglected rat pups fostered by attentive mothers change their histones and their gene expression, might this happen to people?

We considered whether the trajectories and kinetics of particular proteins change in response to histone hyperacetylation by histone deacetylase (HDAC) inhibitors or after suppression of transcription by actinomycin D. We show that protein dynamics are influenced by many factors and events, including nuclear pattern and transcription activity.

Also, the TGS epialleles generated by trans-acting siRNAs did not change their active histone modifications.