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(F ) Resting neuronal membrane potential (V m ), input resistance (R in ), and membrane capacitance (C m ) were not changed by expression of PLE, or exposure to cocaine and CM-MK801.
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In a previous study, we identified genes which expression was changed by CXCL16 expression in metastatic CRC cells.
Remarkably, phospholipid metabolism was changed by ACSL4 expression.
Of the 23 commonly changed genes, 5 (22%) were among most changed by C35 expression: E-cadherin (CDH1), claudin-7 (CLDN7), MAL2, EpCAM (TACSTD1) and HAI-2 (SPINT2).
Several genes were changed by CXCL16 expression, but we focused on IRF8, which is a regulator of apoptosis and the metastatic phenotype.
Globally there were few genes whose expression changed by >1.5-fold.
Those genes, whose expression changed by more than 2-fold, were selected (Additional file 1).
In a living organism, gene expression is changed by chemical stresses.
Neither BAX nor CASP3A gene expression were changed by SeMet treatment.
In agreement with previous results [29], the changes induced by expression of the viral oncoprotein appear associated with enhanced HaCaT cell survival after UV exposure.
DOI: http://dx.doi.org/10.7554/eLife.08527.029 10.7554/eLiFigure27.030 Figure 4 figure supplement 3. Analysis of aging changes clustered by expression profile.
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