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In summary we conclude that the pharmacokinetics of camptothecin are substantially changed by binding it to a polymeric backbone, showing controlled prolonged exposure of camptothecin.
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The internalization kinetics of the wild-type receptor are not changed by LDL binding.
Several studies indicated that the subcellular localization of c-Myc can be changed by its binding partner.
This indicates that the conformation of Rad52 was changed by the binding of the ssDNA−pRPA complex, and/or the affinity of Rad52 for ssDNA is increased by interaction with the ssDNA−pRPA complex.
The function of integrins can rapidly be changed by altering their binding affinity for ligands through inside-out signaling.
Ku70, a DNA repair factor, can prevent the conformational change by binding with Bax in the cytosol, which leads to the inhibition of Bax-mediated cell death.
To determine whether Drosha cleavage in the HeLa nuclear extract is inhibited by the RNA editing base changes or by binding of ADAR2, in vitro transcribed mutant pri-mir-376a2 pri-mir-376a2 pri-mir-376a2ne transcriptse changes at the edited positions were assayed.
This allows for applications to more challenging docking problems that involve conformational changes induced by binding.
This result supports the hypothesis that the MSH2-dependent pathway is initiated by specific protein conformational changes triggered by binding to either DNA damage or small compound molecules.
(B ) SHAPE changes induced by binding of AS 100-113.
(A ) SHAPE changes induced by binding of AS 54-84.
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CEO of Professional Science Editing for Scientists @ prosciediting.com