However, the OA disease process affects not only the cartilage, but also the entire joint structure; and within the bone, cartilage and synovium of affected joints, profound metabolic changes transpire, which include the production of growth factors, nitric oxide (NO), prostaglandins (PGs), leukotrienes (LTs), IL-1β, tumor necrosis factor alpha, IL-6, and IL-8.
First, we see the full acknowledgment that a change has transpired, with no effort to soft-pedal the previous stance.
Where governments have agreed specific treaties, it says, major change has transpired.
Only by identifying where change has transpired as a result of its research, where it has not, and the reasons for this, can it deliver effective research.
If, hypothetically, we could treat a large enough area so that the entire vegetation cover affected by the simulated global change driver transpired differently as in a realistic scenario, plants could in fact be subjected to a series of both positive and negative feedback mechanisms, with an unknown net outcome (Fig. 2).
The most significant changes have transpired in the gallery devoted to Austrian drawings.
Personal changes likely transpire in chess- or seduction-like moves, inch by inch.
These changes that transpire in the red cells during the storage period are referred to as "storage lesions".
Changes that transpire in the island landscape, resulting from subsidence and erosion, will have a significant impact on the number and sizes of populations of endemic species.
