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They believe that this is the first observation of a cultural change transmitted repeatedly on such a large geographic scale.
We can therefore propose that a conformational change transmitted from the ectodomains of the TCRα/β heterodimer to the CD3 tails induces their locked conformation.
This epitope coincides with the PPS in CD3ε and reveals, like the pull-down assay, a conformational change transmitted to the cytoplasmic tail of CD3ε [34].
We suggest that one possibility is that hydrolysis of the substrate in the active site of one oligomeric subunit produces the driving force that leads to a conformational change transmitted to the adjacent subunit.
The results shown in Figures 1D and 1E exclude alternate explanations, and suggest that the acquisition of resistance to trypsin digestion is caused by a conformational change transmitted to the CD3 tails.
The fact that Thr671-Leu690 region known as Peptide A [ 15] is missing in fs-α1S suggests this 20-mer domain is not critical for the conformation change transmitted from the DHPR to the RyR1.
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A major goal is to understand how conformational change transmits information between domains in order to achieve biological activity.
Aristotle, however, subscribes to an even stronger principle, that causes in effecting change transmit the form they possess to the entity they effect change in, so that they have to be synonymous with the effects they bring into existence.
Based on our hypothesis that activation of IDE by activators occurs through conformational changes transmitted from one subunit to the other, we would predict that the monomeric rIDEΔC variant would not exhibit this activation.
The function of MSCs was affected by these morphological changes, transmitted through the activity of RhoA.
This supports the idea that distant conformational changes transmitted along actin participate in the cooperativity of TM binding [14,42].
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