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For example, in the case of Borrelia burgderfori the first ORF is located in the leading strand, so it was included without any change to the sequence.
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Minor changes to the sequence included the Rover SD1 changing into a Ford Sierra in 1993, and again being replaced by a Vauxhall Vectra in 1997.
Evolutionary changes to the sequence of the genome will direct reorganization of GRN architectures, which in turn will lead to the alteration of developmental programs.
Recent findings have confirmed important examples of heritable changes that cannot be explained by changes to the sequence of nucleotides in the DNA.
There are two types of modification to a public sequence record: changes to the sequence, or changes to the annotation or description of that sequence.
"Raw sequence data will be freely available," he says, "but significant changes to the sequence data will be protected".
Interestingly, there are instances in beetles of frame shift mutations causing the mTERF site to become part of the coding region despite no changes to the sequence of the recognition site [ 70].
Introducing changes to the sequence but not the predicted structures would also be useful to help identify the elements that are important in cleavage of sites in the polycistronic unit that are not at tRNA junctions.
We then created a new model in which the β sheet from the crystal structure of the hub domain was retained and the fourth strand was taken from Snrnp, with appropriate changes to the sequence.
Each amino acid codon was changed to the sequence GBC (where B was a 1 1 1 ratio of the bases C, G and T) that introduced the codons GCC (Ala), GGC (Gly) or GTC (Val).
However, even minor changes to the sequence of the RNA DNA hybrid may influence translocation equilibrium (Supplementary Figure 2A) and cause a relatively strong pausing of elongation (Supplementary Figure 3C).
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