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At the same time proteins change their function in evolution and therefore some functional sites are under positive selection to change in order to accommodate new functional specificities.
The lentivirus "vector" delivered instructions for making the tumor antigen to the skin dendritic cells but did not kill them or change their function, as had other vectors.
Viruses have therefore evolved to dissect the cellular DNA damage response pathway during infection, often marking key cellular regulators with ubiquitin to induce their degradation or change their function.
One proposed method is coating poly(glutamic acid -based peptide to the exterior composition of acid -based delivery peptidee to change their function undexteriorvo composition[46].
Thus, it is tempting to speculate that cleavage and release of a self-aggregation domain may be a conserved mechanism that allows cell surface proteins to change their function.
Oncogenes, on the other hand, increase or change their function upon somatic variants in tumorigenesis.
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Sponges have no nervous systems, their middle jelly-like layers have large and varied populations of cells, and some types of cells in their outer layers may move into the middle layer and change their functions.
Suppressive macrophages and DCs change their functions to antitumor effects, such as M2 to M1 phenotype reversing and DCs maturation.
According to the duplication-degeneration-complementation (DCC) model [ 30], degenerative mutations preserve rather than disrupt duplicated genes, but also change their functions or at least restrict their original functions which later might become more specialized.
Darwin, and later Cuènot, recognized that this problem was easily solved if characters that had evolved for one reason changed their function at a later time without any concurrent structural modifications, at least to begin with.
Darwin, and later Cuènot, recognized that this problem was easily solved if characters that had evolved for one reason changed their function at a later time with little to no concurrent structural modification, at least initially.
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