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With rare exceptions, a synonymous mutation is not likely to change the function of the protein and is, therefore, usually considered functionally neutral and not subject to selective pressure (Greenman et al. 2006).
The Harms paper argued that evolution of the protein does not proceed deterministically, because function-changing mutations require prior rare mutations that do not change the function; the rarity of these permissive mutations comes from the fact they must fulfill numerous requirements.
Changing the frequency of some genes that control immune function may inadvertently change the function of other genes and result in adverse effects.
Any subsequent acquisition of genetic differences between the gene copies can alter the chances of both copies being preserved and might change the function of the encoded proteins and result either in gene loss, 'neo-functionalization' [ 38] or 'sub-functionalization' [ 43].
This is the ability to change the function of a chip while it is working.
Unfortunately, at the heart of the draft declaration are a series of proposals which would irrevocably change the function of the European court of human rights and reduce its effectiveness.
There are too many parallels to avoid the corrosive link between the increased calls for repeal of the Human Rights Act 1998 at home and the UK attempts in the chair at the Council of Europe to change the function of the court from enforcer to advisor.
Similar(4)
Be aware that changing file types can change the functions and appearance of a file.
Can I change the functions of the two mouse buttons? A. You can reverse the functions of the buttons on your mouse by going to the Start menu, then to Settings and the Control Panel.
Invasive species can change the functions of ecosystems.
They change the functioning of neurotransmitters, i.e. can actually change the chemistry and engineering of that big wet cauliflower responsible for our thinking.
More suggestions(18)
change the duty
change the relation
alter the function
change the operation
change the performance
change the employment
change the allocation
change the job
change the work
change the business
shift the function
change the capability
change the functionality
change the responsibility
change the assignment
modified the function
changing the function
substituting the function
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