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To change the affinity, hydrogen bonding is induced by modifying surface of PS as poly (vinyl pyrrolidone) (PVP).
In the presence of high levels of GABA, an allosteric shift in the GABAA receptors can change the affinity of benzodiazepine (BZD) ligands.
Although this change is less severe, it could change the affinity and/or specificity of the binding of MAGEC1 to its putative NSE4/EID partner.
The E406A mutation did not significantly change the affinity for cAMP, but decreased the catalytic activity by about 8-fold (Table 2).
We acknowledge that uncertainties in protein concentration, activity, and the fit of the model can also change the affinity measured but the relative order of magnitude of the binding affinities is clear.
At such specific regions the phosphorylation and/or the interaction may change the affinity of the SU VAR 3 9 N-terminus for its specific interactors thereby fine-tuning the molecular composition of SU VAR 3 9 containing complexes.
Similar(33)
Based on in vitro stiudies, we found that this single amino acid substitution changes the affinity of the receptor to glutamate.
Whether methylation changes the affinity to any degree can't be determined.
In particular, substitution at position 4 hardly changed the affinity, confirming that the CGTC central element of the binding site is recognised equally well as CATG, which is preferred by p53.
Because light so changes the affinity of the central chlorophyll pair (P680Chl or P700Chl) in each photosystem involved in oxygenic photosynthesis, an electron will move to an adjacent carrier.
The K108Q mutation didn't change the binding affinity of the androgen substrate, however, it dramatically deceased the binding affinity of reductase.
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