"There was a sea change that occurred with the release of this drug," Portenoy says.
"This is a major change that occurred without anybody thinking through the consequences.
The Egyptian regime change that occurred in July was emphatically not a military coup, according to the Obama administration.
But through a genetic change that occurred at that time, they ceased to produce the vital BMP4 protein at the embryo's tooth-formation stage.
However, the real change that occurred between 1916 and 1918 was that the Roman Catholic church had finally come on board to back the rebel cause.
"It's all part of change that occurred in an instant," Mr. Berkey said, "change that will likely keep coming, fast and furious".
This lieutenant's last sentence provides the key to understanding a significant change that occurred in the Union Army after mid-1863.
The stimulating change that occurred here consists in the fact that truth is no longer measured after the criterion of an exact determination.
Though it would not be Orwell's idea of a fundamental shift of power, his writing certainly contributed to the quieter change that occurred when the Labour Party won the 1945 election, ousted Winston Churchill, and inaugurated the welfare state.
Dissociation of sensibility, phrase used by T.S. Eliot in the essay "The Metaphysical Poets" (1921) to explain the change that occurred in English poetry after the heyday of the Metaphysical poets.
These theorists worked from the perspective that individual conceptual change "recapitulates" the historical conceptual change that occurred within a discipline.
