The percentage change in RAC BPND between active and control tasks was calculated using the formula: Figure 6 shows mean percentage change in striatal RAC BP ND, for all six regions and plotted separately for the two groups.
Confirming the results of the PCR array, combined soy isoflavone treatment did not significantly change Rho, Rac, Cdc42, or Pak levels in primary tumors (data not shown).
We observed a significant negative correlation between mean percentage change in RAC BP ND in the right ventral striatum and learning during trials 101- 150 [ ρ = -.81, p =.03] (Fig. 7).
Mean percent change in RAC BP ND was significantly different between the groups in the right ventral striatum [ t(13) = −2.33, P = 0.04, Cohen's d = 1.5], with the left ventral striatum on the borderline of statistical significance [ t(13) = −1.88, P = 0.08].
We did not observe a striking change of Rac-GTP expression induced by BCL2 expression (data not shown), indicating that there may be an alternate, Rac-GTP-independent, pathway by which BCL2 inhibits gelsolin function and actin depolymerization.
No changes in Rac activity levels were detected at either time point.
DOI: http://dx.doi.org/10.7554/eLife.02839.003 We next tested whether the loss of total Cdc42 led to a decrease of the active form of Cdc42 and/or a compensatory change in active Rac levels.
To determine task- related changes in mean RAC BPND across regions, an ANOVA was performed on mean RAC BPND with Region and Condition (active vs. control) as within subject variables and Group FBB vs. PA) as a between groups variable.
Second, to establish task related changes in mean RAC BPND across regions using a general linear model, an ANOVA was performed on mean RAC BPND with Region and Condition (active vs. control) as within subjects variables and Group FBB vs. PA) as a between groups variable.
In response to GW it has now had a change of heart: "Our RAC patrol wrongly referred to a price match promotion which had finished some time before [GW's] breakdown.
