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Polymorphisms in regulatory regions can change protein expression and may be associated with susceptibility to certain diseases [27].
Our results suggest that human skin might respond to RF-EMF and change protein expression profile.
Insertions in the 5' and 3' region of a gene can change protein expression levels by compromising promoter function and mRNA stability, respectively [ 18, 22, 23], and produce viable mutations in essential genes [ 18].
However, it is difficult to design mRNA sequences for expression at targeted protein levels, since even a few nucleotide modifications around the start codon may alter translational efficiency and dramatically (up to 250-fold) change protein expression.
Flavocoxid did not change protein expression in sham animals, but markedly inhibited the expression of TNF-α and IL-6 in CLP animals (P < 0.005); moreover, IL-10 protein expression was further enhanced after treatment in both lung and liver tissues of septic animals.
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An online database [ 31] was used to assess relevance of significantly changed protein expressions to relapse-free survival.
Changes in protein expression are expressed as a percent of the control values.
Simply measuring an mRNA expression change does not necessary reflect a change in protein expression [46].
To designate significant changes in protein expression, fold-changes >1.5 or <0.66 were set as cutoff values.
We also showed that the hGR mRNA fold change and protein expression alterations are associated with simultaneous cortisol and extracellular or intracellular HSP72 or HSP90α changes.
(b) Summary of the change in protein expression within the CeA at a 24-h withdrawal from 30 days of alcohol drinking under DID procedures, expressed as a percentage of the average protein expression of water-drinking controls (Water).
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