Sentence examples for change of specificity from inspiring English sources

The amino acid substitutions resulting in a partial change of specificity were identified and combined into one superior variant designated NN1.

Mutating the tyrosine to an asparagine in ELF4-DBD led to a clear change of specificity towards that of class III both at +4 and +5.

In contrast, mutation of a class III-specific glutamate that contacts water molecule between positions −1 and 1 (Kodandapani et al, 1996) to a glutamine residue led to a clear change of specificity of ELF4 towards class III at positions −1 and −2.

Here we tested whether amino acid substitutions of NORK have played a role in these changes of specificity, by testing whether more substitutions occurred in branches where these changes occurred.

As this change of substrate specificity was made at the cost of activity, the aim was now to further improve the overall activity of the enzyme.

On the other hand, the log odds ratio log(ψ 01) increases as the sensitivity (i.e., π a1) of alcohol increases when the specificity (i.e., π a0) is kept fixed; the log odds ratio log(ψ 01) appears less sensitive to the change of the specificity (i.e., π a0) when the sensitivity (i.e., π a1) is given.

This transfer would have had to happen after the change of substrate specificity.

Thus the effect of a change of binding specificity may be that a lost gene is rediscovered.

Simulation procedures demonstrated that the change of profile specificity had more instant influence on the performance of expression profiles than the change of profile sensitivity.

In contrast, orthodox Type II R-M systems require two simultaneous concordant mutations in two different genes (REase and MTase) for coordinated change of their specificity.

Nevertheless, we have hypothesized that the twintron arrangement is a safe pathway of intron type switching as it does not involve a dramatic change of spliceosomal specificity and allows step-wise evolutionary changes [ 7].