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However, the spread of the disease did not result in a change of severity in Germany over time.
The paper by Saka and colleagues, however, included additional data from the clinical course before they entered the intensive care unit (age, gender, and ethnicity), thus 'recreating individual patients' whose entire disease course reproduced the rate of change of severity of illness.
The purpose of this investigation is to provide a 'proof-of-concept' that the simulation technique can model individual patients whose aggregated disease course reproduces the rate of change of severity of illness, and the actual outcomes of a multicenter cohort of patients at risk for severe sepsis.
The increased score value ('3' in this example) was used as the reference level (S1, i in equation (1)) for subsequent visits to describe any relative change of severity (decrease or increase) with respect to the visit of addition (the 'reference visit').
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Unlike the results reported by Tan [ 5], the improvement of HFS-36 scores was not proportional to the changes of severity scales in our study.
In summary, this study demonstrated that (a) repeated courses of rTMS treatment cause a significant change of tinnitus severity and (b) the change of tinnitus severity during the intertreatment interval is a good predictor for treatment outcome of the second treatment course with patients whose tinnitus worsens during this interval benefitting most from the second treatment.
Secondary outcomes were recruitment into the trial and change of breathlessness severity after two months, measured on the modified Borg scale.
The data suggest that 127 patients (89%) had noticed a change of varying severity in their bowel habit.
Language function was evaluated by two sensitive measures of change of aphasia severity: the profile score and the Token Test of the Aachen Aphasia Test [ 27].
The primary endpoint is a change of tinnitus severity according to the tinnitus questionnaire of Goebel and Hiller (baseline vs. end of treatment period).
The ACL samples all demonstrated degenerative change of varying severities.
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