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Fig. 2 Percentage change of renal microvascular oxygen tension, oxygen delivery, and consumption from baseline to T3.
In euvolemic dogs, when a RPP is decreased from 153 to 114 mmHg within the range of RBF autoregulation (i.e., with no change of renal blood flow), flow in the inner medulla decreases with no redistribution of flow within the renal cortex [50].
eGFR, CCR, creatinine and BUN are conventional biomarkers reflecting the change of renal function[2], [30].
This study aims to test the hypothesis that elevated FGF21 concentrations are associated with the change of renal function and the presence of left ventricular hypertrophy (LVH) in the different stages of chronic kidney disease (CKD) progression.
In the present study, our data indicated that plasma FGF21 levels are independently associated with β2 microglobulin, and were significantly associated with eGFR, CCR, creatinine and BUN in CKD subjects(Figure 4), suggesting that elevated FGF21 levels are closely related to the injury of glamorous and the change of renal function in CKD patients.
To explore the physiological and pathological relevance of FGF21 in patients with CKD, we measured the plasma concentrations of FGF21 in 240 Chinese subjects and analyzed its association with renal function and a cluster of metabolic parameters that related to the change of renal functions.
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Other mechanisms are likely to contribute to the acute changes of renal function in sepsis.
Blood biochemistry and histopathology were examined to identify specific changes of renal damage.
We also created a non-therapy control group to detect therapy-independent changes of renal function over time.
Moreover, even slight changes of renal function are considered as an independent predictor of 30-day mortality [2].
Several humoral factors control sodium excretion through, in part, changes of renal medulla blood flow and intrarenal redistribution of blood flow.
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