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Second, an algorithm for learning of classifiers used for prediction of the therapy outcome on evaluation of the fold change of pairs and triplets of genes (Support-Vector Machine algorithm together with cross-validation by the leave-one-out method).
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In all situations with low prevalence, estimates are highly sensitive to the number of concordant pairs, where a slight change of two pairs to, for example, one pair has a large impact on point estimates.
The correlation between the change scores of pairs of questionnaires was calculated (Pearson's coefficient).
Thus, our results revealed no evidence for age-related changes of paired-pulse behavior itself.
The change of specific pairs of coexpression relationships in the MA network is also consistent with previous results that showed selective constraint on gene expression divergence among NI populations and accelerated expression divergence for MA lines [ 9].
Modifying the cutoff changed numbers of pairs in different classes in predictable ways.
A change of the paired-pulse ratio from the control value (ratio: 0.85±0.06; paired, paired t-test) was observed only in the first two minutes after the conditioning protocol.
To graphically represent the results economically, we plot the most positive stress change of each pair of nodal planes in Fig. 1, with the convention that where aftershocks overlap, the most positively-stressed shocks are plotted on top.
Next, the heatmap with the fold change of each pair of samples is given.
Finally we provide a heatmap with the fold change of each pair of samples (see Figure 4 (B)).
All of the above methods are very insightful; however, they lack to provide a view that the change of gene pair co-expression pattern results from disease progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com