Sentence examples for change of indication from inspiring English sources
In the evaluation of similarity in the context of orphan drug evaluation, the CHMP needs to decide whether or not an active compound for which a new medicine, or an extension of an existing marketing authorisation (change of indication or line extension), is being sought is similar to an existing orphan drug that has already been authorised.
Another explanation would be a change of indication or physician attitude toward PTX.
This may result in a change of indication for prosthesis use, which has been shown in the Registry (AOANJRR 2011 Annual Report) The Registry is most effective at identifying the performance of recently introduced prostheses, but those prostheses with delayed onset of a higher rate of revision are not identified as readily.
Familiarizing yourself with the new members of your local nine is one of the rites of spring, but looking to roster changes for indications of a team's performance can be tricky business.
In 1982, an experiment running under the leadership of Blas Cabrera, one with eight turns of wire, detected a flux change of eight magnetons: indications of a magnetic monopole.
Essentially, monitoring performance to stated objectives provides evidence of change and indication in the success in achieving desired, or expected results.
Other scientists see Harvey less as a symptom of climate change than an indication of what we can expect in the future.
The change of liquid holdup is an indication of mechanical energy dissipation for inclined or vertical gas liquid flows.
Supporters of same-sex marriage say they hope that Mr. Sweeney's change of heart is just one indication that the tide has shifted.
Some papers estimating the effects of course-specific (or subject-specific) schoolquality inputs on student academic outcomes provide indirectly an indication thatstudents' change of effort in response to changes in school quality may beimportant.
Furthermore, we recorded any change of endocrine agents and the indication for the change: sequential therapy (switching after 2 3 years of adjuvant tamoxifen therapy to an aromatase inhibitor), extended therapy beyond 5 years of adjuvant therapy or change due to adverse effects.
