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To be included patients had to meet the following criteria: a diagnosis of unipolar depression, currently moderate or severe, confirmed with the Mini International Neuropsychiatric Interview (MINI), and current antidepressant treatment (with no change of dose in the preceding three months).
The negative effect of change in residence suggests the child's adherence may reflect household instability and some aspects of routine may be important, although no independent effect was seen for change of caregiver or change of dose.
Factors that were not significant in univariate analyses were early or late entry into the trial, change of primary caregiver, total number of changes in caregiver, child gives himself or herself ART, socioeconomic index (a first principal component based on household possessions), and change of dose.
As we know, respiratory motion may result in the change of dose distribution.
Change of dose of the TNF antagonist or addition of a second drug (not 'biologic' antirheumatic drug) was not considered discontinuation.
Treated with the same antipsychotic drug for at least 3 months before inclusion (change of dose, antipsychotic polypharmacy, and prescription/discontinuation of add-on drugs are allowed but the basic antipsychotic drug must have remained the same).
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For lamotrigine, there is only one RCDBT from 1997 [40], and this study, with a high drop-out rate and change of dosing regimen during the study, failed to show superiority over placebo.
In an observational study of patients (n = 37) resuscitated for septic shock, we analysed hemodynamic PiCCO data at two consecutive time points where the MAP changed by more than 15% in response to either initiation or to change of doses of NE.
Finally, although we captured data regarding the total number of medication changes made throughout the study, we combined changes of dose and changes of prescribed medications.
Both CYP1A2 TDI inactivation parameters produced a significant impact on the AUC of BMS-911543 with changes of dose (Supplementary Figure S4).
In this simulation study, we also had some probabilities close to 0 for abrupt changes of dose between two visit intervals.
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change of radiation
change of administration
change of agent
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alteration of dose
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change of degree
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modifications of dose
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change of clothing
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