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The values of the change of cutoff rigidities obtained by two different methods are correlated with the Dst and interplanetary magnetic field and plasma parameters and result in correlation coefficients in the range 0.63 0.84 for the various cosmic ray stations.
Review of the data reported by Kellogg et al. 14 shows that sensitivity (100%) and specificity (95%) based on cutoff score 4 were both excellent, the change of cutoff score from 4 to 9 only yielded minimal change in specificity (from 95%to9999%), but the authors chose 9 (determined by the chi-square value).
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Genes with a P-value < 0.05 after Benjamini-Hochberg determination of false discovery rate (FDR) were considered significantly changed; a change cutoff value of 1.3-fold was applied.
In this way 238 miRNAs out of 380 miRNAs profiled by microarray were defined as significantly differentially regulated with no magnitude of change cutoff (a loose definition of differential expression) while 105 miRNAs were up or down regulated more than 1.5 fold (a stringent definition, see Methods for details and Additional file 2 and 3 for the complete list of differentially expressed miRNAs).
Mr. Mele's book argued that the Lower East Side has in fact "been a target of change since the cutoff of immigration in the 1920s".
Further refining the 897 gene list to those genes that had an absolute mean fold change (MFC) cutoff of greater than 1.3 in our discovery set resulted in the identification of 151 genes; we define these genes as "geo-ancestral genes" as they encompass both geographical and ancestral-based transcriptional characteristics (Figure 1, Tables 2 and 3).
We used GFOLD v1.0.7 with default parameters and fold change significance cutoff of 0.05.
For identification of differential expressed miRNAs two types of filtering were applied: 1) Loose - using the significance of differential expression p. value cutoff 0.05 and no fold change cutoff; 2) Stringent - using both a p. value cutoff and fold change magnitude cutoff of 1.5.
Warmth detection threshold (WD), cold detection threshold (CD), heat pain detection threshold (HPD), and cold pain detection threshold (CPD) were determined from a baseline temperature of 32°C, with a 1°C/s rate of change and with cutoff temperatures of 10°C and 50°C.
While the tolerance of a capacitor might change the cutoff frequency of a low pass filter or produce ripple in the passband, that same tolerance can produce dramatic changes in center frequency and Q of bandpass and notch filters.
Genes that were defined as differentially expressed were analyzed further using pair-wise comparisons at a significance threshold of P<0.003 and a fold change cutoff of 1.5 for the comparison of interest.
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