Two changes of conclusion were made after re-analysis; one for comparisons by age and the other for a comparison by social deprivation (Townsend index) score.
Since the increase in temperature is gradual, the effect of climate change of the conclusions of this study would be small.
Notice that our assumptions do not seem to be critical: after these assumptions are relaxed, the formal analysis below has to be updated with the correction factors without essential change of the conclusions.
However, consideration of the revised figure with respect to participant flow does not result in any qualitative change of the conclusions of our previous report.
Only the coefficient of the interaction DKO × NR changed from −0.11 to −0.09, but still significant, and not resulting in a substantial change of the conclusions.
Thus the anticipated maximum bias of ±.025 did not change our conclusion of little evidence of an effect of treatment on adenoma recurrence.
Both an increase in precision and a change in statistical significance of the primary outcome were predictive of a change in conclusion of the review.
An increase in the precision of the CI in 2002 compared to 1998 (that is, a decrease in the width of the CI in 2002), increased the odds of a change in conclusion of the systematic review.
The main value of this analysis lies in drawing attention to the previously overlooked assessment of stage of change after the conclusion of formal treatment.
While further trials may narrow the confidence limits, they are unlikely to change the conclusion of lack of benefit.
