Exact(3)
The biological functions of the associated variants in COBLL1 and MACF1 are unknown; variants in the COBLL1 locus may, however, influence expression of nearby GRB14 to change insulin sensitivity [ 6, 29].
We also found that, although IDV acutely reduced insulin sensitivity by an average of 15%, AG did not change insulin sensitivity in IDV-treated healthy volunteers, providing evidence against its use in the treatment of PI-induced disorders of glucose metabolism.
Of 145 who met this primary inclusion criteria, 53 were excluded, 44 were treated with a medication known to result in weight gain/loss or to change insulin sensitivity, 6 lived too far, and 3 were already involved in a weight-management program.
Similar(57)
Changed insulin sensitivity is a biological mechanism that may link membrane fluidity to diabetes risk.
The change in insulin sensitivity correlated with the change in BMI (r = −0.43; P<0.0001).
In both groups, the change in insulin sensitivity correlated with the change in BMI ( r = −0.43; P<0.0001) (Figure 2).
Besides changes in insulin sensitivity, changes in the hepatocyte redox status might be relevant for the liver response to dietary lipid intervention.
For a fixed insulin concentration, a given percentage change of insulin sensitivity results in a proportional change to glucose disposal and thus glycemic level, all else equal.
Equally, for a fixed insulin concentration, a given percentage change in insulin sensitivity results in a proportional change to glucose disposal and thus glycemic level, all else equal.
Moreover, a positive correlation between the change in zinc concentration in serum and the change in insulin sensitivity was observed (R = 0.80, P < 0.01).
This is suggestive of a change in adipocyte metabolism that may lead to a change in insulin sensitivity.
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