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EDP did not change in the present study, and the increase in EDPVR is only due to reduced EDV.
The cholesterol change in the present study was also related to the degree of weight loss, although these associations are not always found [ 21, 39].
This result comports with the HR estimate (converted to 10 μg/m change) in the present study of 1.19 (95% CI: 1.08, 1.31).
As the BOLD effect relies on an increased cerebral blood flow resulting in a change in the blood oxygenation level, a smaller signal change in the present study compared to studies in awake humans had to be expected.
The assessment of additional markers for the NC phenotype, such as KRT8 and KRT19 [ 19, 36], could have improved the insight into the phenotypical change in the present study.
18 The strongest expressions of change in the present study, when compared to the preintervention studies, was the increased awareness about AHC, stronger empathy for patients displayed in more concrete examples of, and fewer explanations, justifications and trivialisations of AHC.
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The biomechanical changes in the present study with LBPPT running contribute to less metabolic cost and corresponding physiological changes.
The latter three items may not be very responsive to changes over relatively short time periods, in fact only item 1 (the well-known global self-rated health item, known as SRH) showed significant changes in the present study.
Moreover, the most important behavioural changes in the present study occur only after the parasitoids have egressed.
It remains unclear whether the NAT1 acetylating capacity is responsible for the observed phenotypic changes in the present study, or whether other mechanisms, such as protein-protein interaction, could account for these changes.
Schizophrenia, a chronic psychiatric disease condition associated with psychosis and widespread cortical dysfunction in the absence of large-scale loss of neurons [44], [45], [46], was not associated with significant methylation changes in the present study.
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