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In order to understand the basis for this drastic change in specificity we have further investigated the target recognition of the IgG4-specific CBMs.
However, the species-specific SNPs in M. sylvanus TRIM5α could also represent a change in specificity or a loss of antiviral activity through genetic drift.
While this calculation is best performed for sequences of identical length and nearly identical sequence (which is not the case for the specific and nonspecific duplexes used in this study), the relative change in specificity as a function of salt is still informative.
However, the overall change in specificity depended on the target compound.
In all cases, a change in specificity was accompanied by a large drop in enzymatic efficiency.
They show up to 1600-fold change in specificity in vitro and methylate the new GATT target site with 20% of the rate of GATC methylation by the wild-type enzyme, indicating good activity.
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We also explored whether changes in goal specificity were associated with comparable changes in specificity of autobiographical memory (quantified as change in number of specific memories retrieved from pre to post treatment or waitlist), again using correlation.
Changes in specificity need to be related to a cost efficacy evaluation in the final analysis of ERSPC.
Changes in specificity may cause phosphorylation and activation of unpredicted targets that lead to disease states.
Further, the functional consequences of changes in specificity of immunological recognition can often be measured in exquisite detail.
Changes in specificity may also result from systematic errors in the expected number of ED visits predicted by the algorithms.
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