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The change in sensitization to food allergens of the participating children during the age period studied will be presented elsewhere.
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What is the association between changes in sensitization and the risk of respiratory disorders?
No change in cocaine sensitization was observed after injection of GR 55562 (0.1 10 μg/side) to the either accumbens subregion or after injection of CP 93129 (0.1 10 μg/side) into the core.
This peripheral process may induce secondary central changes resulting in sensitization of nociceptive neurons at the trigeminal nucleus and/or higher brain structures [3, 4].
Looking further into the OVA adjuvant-free model, we also tested whether varying the site of sensitization induced changes in allergic sensitization; the differences between i.p. and s.c. routes of delivery were examined using Protocol 1B and 1C (Fig. 1).
Change in allergen skin sensitization (mm) was calculated as the difference between the baseline and week-16 saline-adjusted results.
Change in allergen skin sensitization was computed for each allergen by subtracting the baseline saline-adjusted skin prick result in millimetres from the week 12 result.
In addition, we failed to observe differences between NR1DATCre and WT mice with regard to long-term changes in cocaine sensitivity following sensitization [11], and to reinstatement of CPP following extinction [10].
For instance, a subgroup of individuals with knee osteoarthritis (those with higher pain intensity but minimal radiographic change in the knee) exhibiting strong sensitization has been identified [10].
Studies in the headaches field disclosed changes in pain sensitivity that were interpreted as reflecting central sensitization.
Figure 1 Schematic representation of the changes in habituation and sensitization in an healthy subject and over the migraine cycle (interictal, ictal, and chronic migraine due to medication overuse [MOH]).
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