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We did not observe any change in localisation of KRI-1 GFP KRI-1 GFP RNAi against dlc-1 (Supplementary Figure S9).
A change in localisation of Hsp90 in tumours would be predicted to change the pattern of bound Hsp90 clients and may contribute to the specificity of 17-AAG for tumour cells.
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The distribution of aPKC in the ICM presents phases that correlate with phases of gene expression and changes in localisation of PrE cells, suggesting an involvement of aPKC in these processes.
Whether this change in localisation results in remodelling of nuclear actin polymers, resulting in misregulated nuclear-actin processes such as transcription, would make an interesting hypothesis.
We propose that this likely resulted from a change in the localisation of an upstream component capable of recruiting many downstream transcripts, rather than via the sequential evolution of distinct localisation mechanisms for individual transcripts.
This suggests that the evolution of germ plasm in Holometabolous insects involved a large-scale change in the localisation of many transcripts in the oocyte.
Close to 89% of the women in the 'continuous pain' group and 66% of the women in the 'recurrent pain' group reported no change in the localisation of pain (as reported in Q1) at Q3 compared to the first 6 months postpartum.
However, this is not reflected by any convincing changes in the localisation of Mdm2 in the presence of LMB by either immunocytofluorescence or cell fractionation experiments (data not shown).
This finding suggests that changes in the localisation of p-mTOR may be involved in tumour progression.
Such changes in cellular localisation of hnRNP K has also been observed in smooth muscle cells (SMC).
As a matter of fact, immunogold-labeling experiments, using the anti-VDAC antibody in 16 mM BCD treated pollen tubes revealed changes in the localisation of these proteins with respect to control.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com