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Patients who underwent surgery or received radiotherapy appeared, by evaluation of the HR, to have an even more dramatic change in fate than was apparent on univariate analysis.
Ngn3-null mice also displayed an accompanying increase in Npy+ cells in the ARC that is suggestive of a change in fate of developing ARC cells from Pomc-expressing to Npy-expressing (Pelling et al., 2011).
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Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental inter-relationships between osteoblasts and adipocytes and the impact of changes in fate allocation between the two lineages in normal aging and certain diseases.
For acids and bases that are less than 50%% ionized in freshwater, the changes in fate factors are relatively small (<10 %) (Van Zelm et al. 2013).
In addition to proliferation, NSCs activity can also be regulated at the level of a change in their fate (e.g.: by changing the proportion of cells undergoing proliferative versus differentiative, symmetric versus asymmetric, and/or gliogenic versus neurogenic divisions).
More importantly, a change in the fate of the microzooplankton within the food web can be monitored through the trophic level of mesozooplankton.
Only AP2C3 led to a dramatic change in cell fate that in extreme cases resulted in the conversion of all epidermal cells into stomata.
This change in cell fate is thought to occur as mouse PGCs already express several pluripotency markers and respond to growth factors present in the culture medium [8].
By contrast, in lineages with type B PROS expression, the LOF of pros seems to cause primarily a change in the fate of the putative GMC that behaves like a NB maintaining the expression of asymmetric division genes (such as MIRA) and overproliferating, to yield a type B clone composed of multiple large NB like cells (Fig. 7A,B).
It is thus the change in cell fate caused by Notch3 signalling that leads ultimately to T-cell lymphoma.
The changed location of mitotic progenitors to different niches during evolution often results in a change in cell fate (Rompolas et al., 2013; Inan et al., 2012).
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