Although detailed mechanisms for RNA binding are not known, amino acid changes in PPR proteins have been associated with changes in editing efficiency [ 22- 25], and this observation suggests that there is significant co-evolution between nuclear-encoded editing factors and organellar RNA cis-elements.
Overall, there is a positive correlation between C-to-U RNA editing and GC content of the genome [ 9], so it is likely that it is mutation/repair processes at the genome level that are driving changes in editing frequency over evolutionary timescales.
We used a regression through the origin to explore the relationship [ 50] between dS and number of changes in edited sites.
On a recent episode of the "Happy Sad Confused" podcast, the Russo brothers told host Josh Horowitz that the upcoming "Avengers" movie is mostly filmed but could change a lot in editing.
It's not something that will absorb other media, apparently it will transform them and make changes in editing, shooting and screening," adds Tereshchenko, discussing what VR can uniquely offer filmmakers.
Although no changes in editing levels were observed after KA injection, the observed decrease in GluR3 R/G site editing might cause a selective reduction of conductance for GluR3-containing receptors after KA.
Specifically, several reports clearly indicate that changes in editing of specific glutamate receptor subunits are accompanied by corresponding changes in the physiological properties of the channels [23], [26], [27], [58].
Changes in editing levels and gene expression following ADAR1 knockdown were not significantly correlated (r < 0.05).
As there are several examples of multiple editing sites within a single transcript that respond differently to temperature (see Additional file 4: Figure S3), it is unlikely that the observed changes in editing are due to fluctuating transcript levels.
Because ADARs recognize duplex RNA structures, the information directing editing is carried in RNA secondary and tertiary structures, and changes in editing should partially reflect thermal alteration in RNA shapes [ 8].
