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9 If a point of care information summary still cited the old version of the Cochrane systematic review this was considered not updated, regardless of the nature and impact of the change in conclusions.
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Of these updated reviews, 23 (9%) had a change in conclusion.
A large percentage (50%) of the eighteen reviews excluded from our analysis had a change in conclusion.
Both an increase in precision and a change in statistical significance of the primary outcome were predictive of a change in conclusion of the review.
For eight of these reviews, the change in conclusion was related to a change for an outcome other than the primary outcome.
Chapman and colleagues [ 3] suggested that over three years, only a small percentage of updated reviews actually resulted in a change in conclusion.
Therefore, for a 19.1% increase in precision, as was observed on average between 1998 and 2002, the odds of a change in conclusion were 85.7%9595% CI; 21.1%, 184.6%) higher than those of no change in precision.
We examined whether a change in statistical significance of the summary statistic of the primary outcome was associated with a change in conclusion of the systematic review, using an exact 95% CI [ 10] for a difference in proportions.
Those with lower mood had worse scores on all of the subscales but there was no change in conclusion where DIF free totals were used and no change in effect size.
An increase in the precision of the CI in 2002 compared to 1998 (that is, a decrease in the width of the CI in 2002), increased the odds of a change in conclusion of the systematic review.
In particular, for each percentage increase in the precision of the CI in 2002, the odds of a change in conclusion were 3.3%9595% CI; 1.0%, 5.6%) higher than the previous odds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com